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UPTAKE is proud to share the following article first-authored by Ivy Kayesu, MSc candidate at MRC/UVRI & LSHTM Uganda Research Unit and one of four UPTAKE scholars. This paper was made possible through IAVI's ADVANCE program, a 10-year cooperative agreement with the U.S. Agency for International Development (USAID), through the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR).


Kayesu, I., Mayanja, Y., Nakirijja, C., Machira, Y., Price, M., Seeley, J., Siu, G. Uptake of and adherence to oral pre-exposure prophylaxis among adolescent girls and young women at high risk of HIV-infection in Kampala, Uganda: A qualitative study of experiences, facilitators and barriers. BMC Women's Health. November 2022. ​

There is limited information on factors that influence oral pre-exposure prophylaxis (PrEP) uptake and adherence among adolescent girls and young women (AGYW). We conducted a qualitative methods study to explore experiences, facilitators and barriers of PrEP uptake and adherence to PrEP among AGYW at risk of Human Immunodeficiency Virus (HIV) infection in Kampala, Uganda.

Wangũi Machira, Y., Kuteesa, M., Gao, L., Muthike, W., Anzala, O., Omosa-Manyonyi, G., Gafos, M., Quaife, M, Neuman, M., Indravudh, P., Mayanja, Y., & Kamali, A. Behavioural Determinants of Uptake of Long-Acting HIV and Multi-Purpose Prevention Technologies among Adolescent Girls and Young Women (AGYW) and Female Sex Workers (FSW) in Kenya and Uganda. 10th EDCTP Forum. October 2021. 

AGYW and FSW in sub-Saharan Africa are vulnerable and susceptible to HIV, sexually transmitted infections, and unplanned pregnancies. End-user research that considers their needs, preferences and behaviour is critical to inform design, development, access to and uptake of long-acting HIV (LA-HIV) and multi-purpose prevention technologies (MPTs). Understanding health system and programmatic perspectives from healthcare providers (HCPs) and policymakers (PMs) is also critical towards product introduction.

Lunani, L.L., Namukwaya, S., Lipesa, S., Kombo, B., Omodi, D., Shikuku, J., Omom, C., Maina, A, Malogo, R., Katumba, K., Kayesu, I., Nabalwanyi, Z., Naluwooza, R., Mayanja, Y., Omosa-Manyonyi, G., Anzala, O., Indravudh, P., Quaife, M., Gao, L., Kuteesa, M., Machira, Y., Kamali, A., and Gafos, M. Perspectives and Preferences for Multi-Purpose Prevention Technologies (MPTs) to Address Sexual and Reproductive Health (SRH) Needs Among Adolescent Girls and Young women (AGYW) in Nairobi and Kampala. AIDS 2022, Montreal. July 2022. 

AGYW in Sub Saharan Africa are disproportionately affected by high rates of HIV, sexually transmitted infections (STIs) and unintended pregnancies. To inform development of MPTs and delivery of SRH services, an innovative behavioural science research project (UPTAKE) seeks to determine factors that facilitate future acceptability and uptake of long-acting (LA) technologies to prevent HIV and unintended pregnancy among AGYW in Nairobi, Kenya and Kampala, Uganda.

Namukwaya, S., Katumba, K., Kayesu, I., Nabalwanyi, Z., Naluwooza, R., Mayanja, Y., Indravudh, P., Quaife, M., Gao, L., Kuteesa, M., Machira, Y., Kamali, A., Seeley, J., and Gafos, M. Female sex workers’ preferences for Multi-Purpose Technologies (MPTs) to prevent HIV, other Sexually Transmitted Infections (STIs) and unintended pregnancies in Kampala, Uganda. AIDS 2022, Montreal. July 2022. 


To inform the development of MPTs, a formative study to explore FSWs preferences for future HIV prevention MPTs was conducted as part of a larger innovative behavioural science research project (UPTAKE) that is seeking to determine factors that facilitate future uptake of long-acting technologies to prevent HIV and unintended pregnancy among FSWs in Nairobi, Kenya and Kampala, Uganda.

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